中文名称磺胺氯吡嗪钠中文同义词磺胺氯吡嗪;N-(5-氯-3-吡嗪基)-4-氨基苯磺酰胺;磺胺氯吡嗪鈉;磺胺氯毗嗪钠;磺胺氯吡嗪钠/三字球虫粉;磺胺氯吡嗪(标准品);磺胺氯吡嗪溶液,100PPM;磺胺氯吡嗪钠一水合物英文名称N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININO英文同义词N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININOSODIUMMONOHYDRATE;SULFACHLOROPYRAZINESODIUM;SULFACHLOROPYRAZINESODIUMH2O;SULFACHLORPYRAZINESODIUM;sulfaclozine;SULFACLOZINESODIUM;SPZ;SULFACHLOROPYRAZINESODIUM(SPZ):N-(5-CHLORO-3-PYRAZINE)-4-AMINOBENZENESULFONAININOSODIUMMONOHYDRATECAS号102-65-8分子式C10H9ClN4O2S分子量284.72EINECS号203-044-0相关类别磺胺类产品;生命科学标准品;兽药原料药;原料药;原料药;原料中间体-原料药;兽药;医药原料;中间体;农用兽用原料;Pharmaceuticalintermediate;pharmaceutical;1;API原料药- ;药物杂质及中间体;标准品-中药标准品;兽药原料药;原料;添加剂;化工材料;医药、农药及染料中间体PI原料药-兽药原料药;化学试剂-兽用原料;定制;化工原料;化学试剂Mol文件102-65-8.mol结构式磺胺氯吡嗪钠性质熔点234.8-235.4°C沸点495.7±55.0°C(Predicted)密度1.588±0.06g/cm3(Predicted)储存条件2-8°C(protectfromlight)溶解度DMSO（轻微）、甲醇（轻微、加热、超声处理）酸度系数(pKa)4.83±0.10(Predicted)形态固体颜色白色至类白色磺胺氯吡嗪钠用途与合成方法生物活性Sulfalozinesodium(Sulfaclozinesodium,Sulfachlopryrazinesodium)是一种抗原生动物药，用于球虫病的研究。靶点Bacterial;Parasite体外研究TheeliminationofSulfaclozineinthethreesystems:UV/TiO2,UV/K2S2O8,andUV/TiO2/K2S2O8.SulfaclozineisweaklyadsorbedonthesurfaceofTiO2atpH7(<5%)butefficientlyeliminatedwiththefollowingthreesysteChemicalbookms:UV/TiO2,UV/K2S2O8,andUV/TiO2/K2S2O8inultrapurewater.Moreover,12ofSulfaclozineby-productsareidentifiedandreactionpathwaysshowthat,inadditionof?OHandSO4??radicals,theconduction-bandelectronsareresponsiblefortheformationofsomemainby-productseitherdirectlyorbytheformationofsuperoxideradicals.体内研究Sulfaclozine(60mg/kg;intravenousinjectionororaladministration;malebroilerchickens)canbeusedprimarilyforthetreatmentofparasiticandmicrobialinfectionsofthedigestivetractratherthanforthetreatmentofsystemicinfections.AnimalModel:14malebroilerchickens(30-day-old)Dosage:60mg/kgAdministration:Intravenousinjectionororaladministration(PharmacokineticAnalysis)Result:Serumdrugconcentrationsat0.083,0.50,2,6,24and72hweredeterminedtobe99.62,83.50,72.68,58.43,38.66and13.14μg/mL,respectively,byintravenousinjection.Byoraladministrationweredeterminedas4.33,7.95,16.46,22.88,16.03and5.74μg/mL,respectively.用途磺胺氯吡嗪钠为抗球虫的专用磺胺药，广泛用于畜禽球虫病。本品可争夺二氢叶酸合成酶影响二氢叶酸的合成，从而于畜禽球虫病。本品可争夺二氢叶酸合成酶影响二氢叶酸的合成，从。本品对家禽球虫的作用特点与磺胺喹沙啉相似，但具更强的 作用，甚至可 禽霍乱及鸡伤寒因此 球虫病爆发时 用。用途磺胺类 药，用于禽畜大肠杆菌和巴式杆菌感染，与甲氧苄啶与蔗糖配置而成复方磺胺氯哒嗪钠盐效果更加，对磺胺类药过敏者忌用，肾功能减退者慎用。